Director: Thomas L. Ortel, M.D., Ph.D. (Hematology)
co-Director: Andra H. James, M.D. (Maternal-Fetal Medicine)
co-Director: Sherri Zimmerman, M.D. (Pediatric Hematology)

The Hemostasis & Thrombosis Center at Duke integrates inpatient and outpatient clinical services with clinical, translational, and basic research programs. The Thrombophilia Program is one of eight national pilot programs supported by the Centers for Disease Control and Prevention. The Center also participates in the Antiphospholipid Syndrome Collaborative Registry and the Women’s Initiative in Hemostatic Disorders. This Program provides close clinical and research collaborative efforts between clinicians and investigators in multiple subspecialties, including Medicine, Surgery, Obstetrics & Gynecology, Radiology, and Pediatrics. Opportunities also exist to rotate through the Hemostasis & Thrombosis Laboratory and interact with programs in the Department of Pathology.

Clinical Services: Clinical programs include the Hematology Inpatient and Consultation Service, as well as the following outpatient clinics: Adult Hemostasis & Thrombosis Clinic, Women’s Hemostasis & Thrombosis Clinic, Pediatric Hematology Clinic, the Anticoagulation Management Service, and the Surgical Thrombosis Clinic. Fellows interested in selected subspecialty opportunities can rotate through individual clinical services to broaden their exposure to include a wide variety of consultative issues related to hemostasis.

Clinical Research Programs: Clinical research studies involve the application of new diagnostic studies as well as development of novel therapeutic interventions. Clinical research opportunities in the Hemostasis & Thrombosis Center are available with the following investigators (partial list):

Kimberly Blackwell, M.D. – Use of Direct Thrombin Inhibitors for Metastatic Cancer.
Cheryl Bushnell, M.D. – Impact of Hormone Replacement Therapy on Stroke Outcomes.
Joseph Govert, M.D. – Early Diagnosis of DIC Using Coagulation Waveform Profiles.
Andra H. James, M.D. – Hypercoagulable States and Intrauterine Growth Restriction.
Andrea Lukes, M.D. – Hemorrhagic Disorders in Women with Menorrhagia.
Susan I. O’Shea, M.D. (with TLO) – Telemedic ine and Anticoagulant Management Strategies.
Thomas L. Ortel, M.D., Ph.D. – Therapeutic Strategies in Antiphospholipid Antibody Syndromes.
Victor Tapson, M.D. – Diagnostic and Therapeutic Strategies in Venous Thromboembolism.

Basic Research Programs: The following investigators provide research opportunities for basic scientific investigations into normal and abnormal hemostatic mechanisms (partial list):

Gowthami Arepally, M.D. – Molecular Basis of Heparin-Induced Thrombocytopenia.
Charles S. Greenberg, M.D. – Tissue Transglutaminases and Cancer Metastasis.
Maureane Hoffman, M.D., Ph.D. – Cell-Based Model of Hemostasis.
William H. Kane, M.D., Ph.D. – Molecular Biology of Coagulation Factor V.
Michael Kelley, M.D. – Genetics of Hereditary Macrothrombocytopenias.
Jeffrey H. Lawson, M.D., Ph.D. – Immunologic Consequences of Thrombin Exposure.
Thomas L. Ortel, M.D., Ph.D. – Structure-Function Relationships of Coagulation Factor VIII.
Claude A. Piantadosi, M.D. – Coagulation Blockade in Acute Lung Injury.
Chris Rusconi, Ph.D. & Bruce Sullenger, Ph.D. – Aptamers as Coagulation Inhibitors.